[PDF] Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth | Semantic Scholar (2025)

Skip to search formSkip to main contentSkip to account menu

Semantic ScholarSemantic Scholar's Logo
@article{Koo2019InductionOA, title={Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth}, author={Ja Hyun Koo and Steven W Plouffe and Zhipeng Meng and Dahye Lee and Di Yang and Dae-Sik Lim and Cun-Yu Wang and Kunliang Guan}, journal={Genes \& Development}, year={2019}, volume={34}, pages={72 - 86}, url={https://api.semanticscholar.org/CorpusID:209342042}}
  • Ja Hyun Koo, Steven W Plouffe, K. Guan
  • Published in 12 December 2019
  • Biology, Medicine

It is identified that YAP/TAZ are directly involved in immediate early gene induction, including AP-1; and this AP- 1 induction by YAP is essential for the functions of YAP in organ size control and cancer cell growth.

75 Citations

Highly Influential Citations

2

Background Citations

22

Methods Citations

1

Results Citations

3

Figures from this paper

  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6
  • figure 7

75 Citations

Context-dependent transcriptional regulations of YAP/TAZ in cancer.
    Yibo GuoJuan LuoHailin ZouChenxin LiuL. DengPeng Li

    Medicine, Biology

    Cancer letters

  • 2021
  • 22
New insights into the ambivalent role of YAP/TAZ in human cancers
    Juan LuoL. Deng Peng Li

    Medicine, Biology

  • 2023

An overview of YAP/TAZ and their oncogenic roles in various cancers and their tumor-suppressive functions in different contexts are given and the clinical implications of YAP/TAZ-based tumor targeted therapy are discussed.

CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway Activation in Liver Cancer
    Marie C. WesenerS. Weiler K. Breuhahn

    Medicine, Biology

    International journal of molecular sciences

  • 2024

The data illustrate that CRKL not only promoted YAP activity through its binding but also through the induction of YAP transcription by JNK/JUN activation, emphasizing the potential use of targeting the JNK/JUN pathway to suppress YAP expression in HCC patients.

Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis
    B. KingJingwen ArakiWilhelm PalmC. Thompson

    Biology, Medicine

  • 2020

The results indicate that the Hippo pathway effectors Yap and Taz are important transcriptional regulators of endocytic nutrient uptake.

YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice
    Jaeoh ParkDavid Eisenbarth D. Lim

    Medicine, Biology

    Cancer Research

  • 2020

Both YAP and AP-1 were activated during the development of KRAS-dependent cancer in mice and human patients with pancreatic ductal adenocarcinoma, suggesting that this signaling hub represents an important mediator of pancreatic cancer development and progression.

  • 29
  • PDF
The JNK and Hippo pathways control epithelial integrity and prevent tumor initiation by regulating an overlapping transcriptome
    Katrina A. MitchellJ. Vissers Kieran F. Harvey

    Biology, Medicine

    Current Biology

  • 2024

Targeted DamID experiments reveal that in proliferating cells of the Drosophila melanogaster eye, the AP-1 transcription factor Jun, and the Hippo pathway transcription regulators Yorkie and Scalloped bind to a common suite of target genes that regulate organ growth.

  • PDF
A noncanonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth
    Yuliya V. KurlishchukAnita Cindric Vranesic B. Eyss

    Medicine, Biology

    bioRxiv

  • 2023

It is reported that the AP-1 component c-JUN acts as specific repressor of YAP/TAZ at joint target sites to decrease YAP/, and a negative feedback loop needs to get disrupted in liver cancer to unlock the full oncogenic potential of Yap/TAz.

  • PDF
The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment
    R. MokhtariN. Ashayeri Sayan Chakraborty

    Medicine, Biology

    Cancers

  • 2023

An integrated summary of the contrasting roles of YAP/TAZ during normal tissue homeostasis versus tumor initiation and progression and an exciting perspective on developing inhibitors that intervene with YAP-TAZ signaling with a close focus on the immune-microenvironmental regulations is developed.

YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance.
    Frank SzulzewskyE. HollandV. Vasioukhin

    Medicine

    Developmental biology

  • 2021
  • 80
  • PDF
A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth
    Yuliya V. KurlishchukAnita Cindric Vranesic Björn von Eyss

    Medicine, Biology

    The EMBO journal

  • 2024

The AP-1 component JUN acts as specific repressor of YAP/TAZ at joint target sites to decrease YAP/TAZ activity, demonstrating an additional layer of control for the interplay of YAP/TAZ and AP-1.

  • PDF

...

...

50 References

The emerging roles of YAP and TAZ in cancer
    T. MoroishiC. G. HansenK. Guan

    Medicine, Biology

    Nature Reviews Cancer

  • 2015

The current understanding of the biological functions of YAP and TAZ is summarized, and how the regulation of these two proteins can be disrupted in cancer is described.

  • 972
  • Highly Influential
  • PDF
TEAD mediates YAP-dependent gene induction and growth control.
    Bin ZhaoX. Ye K. Guan

    Biology, Medicine

  • 2008

TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition.

  • 2,180
  • PDF
Cell type-dependent function of LATS1/2 in cancer cell growth
    Wei-Wei PanT. MoroishiJa Hyun KooK. Guan

    Biology, Medicine

    Oncogene

  • 2018

It is demonstrated that the function of LATS1/2 in cell growth is cell context dependent, suggesting that LATS 1/2 inhibition can be a therapeutic approach for some cancer types.

  • 29
  • Highly Influential
  • PDF
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
    T. MoroishiH. Park K. Guan

    Biology, Medicine

  • 2015

It is shown that YAP and TAZ activation induces the negative regulators LATS1 kinase and LATS2 kinase to constitute a negative feedback mechanism to control YAP/TAZ activation duration and cellular response.

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
    Bin ZhaoXiaomu Wei K. Guan

    Biology, Medicine

  • 2007

It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.

  • 2,780
  • PDF
The biology of YAP/TAZ: hippo signaling and beyond.
    S. PiccoloS. DupontM. Cordenonsi

    Biology, Medicine

    Physiological reviews

  • 2014

YAP/TAZ appear at the centerpiece of a signaling nexus by which cells take control of their behavior according to their own shape, spatial location and growth factor context, and are appealing therapeutic targets in cancer and regenerative medicine.

  • 1,429
  • PDF
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
    Fa-Xing YuBin ZhaoK. Guan

    Medicine, Biology

    Cell

  • 2015
  • 1,790
  • Highly Influential
  • PDF
The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell
    Steven W PlouffeKimberly C. Lin K. Guan

    Biology, Medicine

    The Journal of Biological Chemistry

  • 2018

It is found that YAP inactivation has a greater effect on cellular physiology than TAZ inactivation, and this confirms that the Hippo pathway effectors YAP and TAZ are master regulators for multiple cellular processes but also reveals that Yap has a stronger influence thanTAZ.

  • 167
  • Highly Influential
  • PDF
The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1
    C. G. HansenYuen Lam Dora NgWai-Ling Macrina LamSteven W PlouffeK. Guan

    Biology, Medicine

    Cell Research

  • 2015

This study shows that YAP/TAZ play an essential role in amino acid-induced mTORC1 activation, particularly under nutrient-limiting conditions, and provides molecular insight into the mechanism of YAP-TAZ target genes in cell growth regulation.

  • 168
  • PDF
Genome-wide association between YAP/TAZ/TEAD andAP-1 at enhancers drives oncogenic growth
    Francesca ZanconatoM. Forcato S. Piccolo

    Biology, Medicine

    Nature Cell Biology

  • 2015

This work highlights a new layer of signalling integration, feeding on YAP/TAZ function at the chromatin level, which occurs almost exclusively from distal enhancers that contact target promoters through chromatin looping.

  • 914
  • Highly Influential
  • PDF

...

...

Related Papers

Showing 1 through 3 of 0 Related Papers

    [PDF] Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth | Semantic Scholar (2025)

    References

    Top Articles
    Latest Posts
    Recommended Articles
    Article information

    Author: Laurine Ryan

    Last Updated:

    Views: 6306

    Rating: 4.7 / 5 (57 voted)

    Reviews: 80% of readers found this page helpful

    Author information

    Name: Laurine Ryan

    Birthday: 1994-12-23

    Address: Suite 751 871 Lissette Throughway, West Kittie, NH 41603

    Phone: +2366831109631

    Job: Sales Producer

    Hobby: Creative writing, Motor sports, Do it yourself, Skateboarding, Coffee roasting, Calligraphy, Stand-up comedy

    Introduction: My name is Laurine Ryan, I am a adorable, fair, graceful, spotless, gorgeous, homely, cooperative person who loves writing and wants to share my knowledge and understanding with you.